Ozempic Halts CKD Trial Early with Success


Nov 7, 2023

Ozempic Halts CKD Trial Early with Success

Ozempic's Early Chronic Kidney Disease Trial Success

A Triumph in Clinical Trials

In a decisive and unexpected move, Novo Nordisk has ceased its Ozempic trial for kidney failure in diabetes patients ahead of schedule. The decision follows an interim analysis indicating the drug’s efficacy, suggesting that Ozempic could successfully treat this complication.

The Independent Board's Role

Guided by the recommendations of an independent data monitoring board, this early halt reflects the drug's clear potential based on initial results. Such boards are crucial in maintaining the integrity of clinical trials, ensuring that any significant findings are acted upon promptly.

Ozempic's Wider Therapeutic Impact

The trial aimed to explore Ozempic's ability to slow chronic kidney disease progression and reduce mortality from related kidney and heart issues. This development signifies a potential expansion in the use of semaglutide, also the active ingredient in Novo Nordisk's weight-loss drug Wegovy.

Industry Implications

Barclays analyst Emily Field notes this confirms the broader therapeutic reach of GLP-1 receptor agonists like Ozempic, initially developed for diabetes management. Novo Nordisk's market presence has grown significantly, spurred by demand for semaglutide-based treatments. Their success has propelled the company to an impressive $315 billion valuation, with a marked increase in share price following cardiovascular benefits reported from Wegovy use. The company's achievements have not only revolutionized treatment for diabetes and CKD but also sparked an economic upturn in Denmark, with effects noted by various national economic experts and the Novo Nordisk Foundation.

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About the Author

Rich Foreman brings over 30 years of technology leadership to his role of CEO and Co-Founder of KidneySoft.  As founding CTO, Rich led the team that developed the CordicoShield / CordicoFire Wellness App. Cordico was honored with the Sacramento Innovation Award in 2021. After achieving a 7 digit ARR, Cordico was acquired by Lexipol in 2020. Rich has a BS in Industrial Engineering from the University of Washington, an MPA from Troy State University and was an officer in the U.S. Navy. Rich co-authored his book, "Tap into the Mobile Economy." Rich's blog was listed in Top 20 Marketing Mobile Blogs of 2014. He has been featured on KCRA3, NEWS10, 1170 Tech AM PowerDrive, Business Radio Money 105.5, SiliconIndia, the Sacramento Business Journal, and the Sacramento Bee. Rich is also the Founding Director of the Sacramento Chapter of Startup Grind and served a term as Utility Commissioner for the City of Folsom. Rich is a regular contributor to TechWire.net and StartupSac. Rich was the Co-founder of Apptology which was named Small Business of the Year in 2014 by the Sacramento Asian Pacific Chamber. He was also the Founding Chief Technology Officer at Cordico. Cordico was acquired by Lexipol in 2020.  Rich also served 4 years as a Naval Officer in the Civil Engineer Corps.

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